USE: SYNTHROID® (levothyroxine sodium) tablets, USP

for oral use is a prescription, man-made thyroid hormone that is used to treat a condition called hypothyroidism. It is meant to replace a hormone that is usually made by your thyroid gland. Generally, thyroid replacement treatment is to be taken for life. SYNTHROID should not be used to treat noncancerous growths or enlargement of the thyroid in patients with normal iodine levels, or in cases of temporary hypothyroidism caused by inflammation of the thyroid gland (thyroiditis).

IMPORTANT SAFETY INFORMATION

  • Thyroid hormones, including SYNTHROID, should not be used either alone or in combination with other drugs for the treatment of obesity or weight loss. In patients with normal thyroid levels, doses of SYNTHROID used daily for hormone replacement are not helpful for weight loss. Larger doses may result in serious or even life-threatening events, especially when used in combination with certain other drugs used to reduce appetite.

  • Do not use SYNTHROID if you have uncorrected adrenal problems.

  • Taking too much levothyroxine has been associated with increased bone loss, especially in women after menopause.

  • Once your doctor has found your specific SYNTHROID dose, it is important to have lab tests done, as ordered by your doctor, at least once a year.

  • Foods like soybean flour, cottonseed meal, walnuts, and dietary fiber may cause your body to absorb less SYNTHROID from the gastrointestinal tract. Grapefruit juice may cause your body to absorb less levothyroxine and may reduce its effect. Let your doctor know if you eat these foods, as your dose of SYNTHROID may need to be adjusted.

  • Use SYNTHROID only as ordered by your doctor. Take SYNTHROID as a single dose, preferably on an empty stomach, one-half to one hour before breakfast.

  • Products such as iron and calcium supplements and antacids can lower your body’s ability to absorb levothyroxine, so SYNTHROID should be taken 4 hours before or after taking these products.

  • Tell your doctor if you are pregnant or breastfeeding or are thinking of becoming pregnant while taking SYNTHROID. Your dose of SYNTHROID may need to be increased during your pregnancy.

  • It may take several weeks before you notice an improvement in your symptoms.

  • Tell your doctor if you are taking any other drugs, including prescription and over-the-counter products.

  • Tell your doctor about any other medical conditions you may have, especially heart disease, diabetes, blood clotting problems, and adrenal or pituitary gland problems. The dose of other drugs you may be taking to control these conditions may have to be changed while you are taking SYNTHROID. If you have diabetes, check your blood sugar levels and/or the glucose in your urine, as ordered by your doctor, and immediately tell your doctor if there are any changes. If you are taking blood thinners, your blood clotting status should be checked often.

  • Tell your doctor or dentist that you are taking SYNTHROID before any surgery.

  • Tell your doctor if you develop any of the following symptoms: rapid or abnormal heartbeat, chest pain, difficulty catching your breath, leg cramps, headache, nervousness, irritability, sleeplessness, shaking, change in appetite, weight gain or loss, vomiting, diarrhea, increased sweating, difficulty tolerating heat, fever, changes in menstrual periods, swollen red bumps on the skin (hives) or skin rash, or any other unusual medical event.

  • Partial hair loss may occur during the first few months you are taking SYNTHROID.

This is the most important safety information you should know about SYNTHROID. For more information, talk with your doctor.

Click here for full Prescribing Information or go to http://www.rxabbvie.com/pdf/synthroid.pdf.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1‑800‑FDA‑1088.

If you cannot afford your medication, contact www.pparx.org for assistance.

What is Synthroid?

Synthroid is a prescription medication that can help treat hypothyroidism. The active ingredient in Synthroid is called levothyroxine sodium. Synthroid can help restore thyroid hormone balance. It is a man-made thyroid hormone identical to thyroxine, the hormone that’s naturally made by the thyroid gland.

Synthroid is a narrow therapeutic index (NTI) medication. With NTI medications, if your dose is off even a little bit, your TSH level may change. Because of this, your doctor will carefully titrate your dose because it is important to avoid under-replacement (not enough medicine) or over-replacement (too much medicine). Generally, hypothyroid medication is to be taken for life.

Safety Considerations

  • Thyroid hormones, including SYNTHROID, should not be used for the treatment of obesity or weight loss. Large doses of thyroid hormone, especially when used with certain drugs that reduce appetite, can result in serious and even life-threatening effects.
  • Do not use SYNTHROID if you have uncorrected adrenal problems.
  • Excessive amounts of levothyroxine sodium therapy have been associated with decreased bone strength, especially in women after menopause.
  • Talk to your doctor about all medications you are taking, pregnancy plans, and all medical conditions you may have, especially heart disease, diabetes, blood clotting problems, and adrenal or pituitary gland problems. The dose of other drugs you may be taking to control these conditions may have to be changed while you are taking SYNTHROID. Tell your doctor if you are taking SYNTHROID prior to any surgery.
  • Tell your doctor if you experience rapid or abnormal heartbeat, chest pain, difficulty catching your breath, leg cramps, headache, nervousness, irritability, sleeplessness, shaking, change in appetite, weight gain or loss, vomiting, diarrhea, increased sweating, difficulty tolerating heat, fever, changes in menstrual periods, swollen red bumps on the skin (hives) or skin rash, or any other unusual medical event.

How does Synthroid Work?

In most cases, you will take thyroid replacement medication every day as your doctor prescribed. When you first start taking Synthroid, it’s very important for your doctor to monitor you closely. He or she will usually test your TSH levels every 6 to 8 weeks to make sure you’re on the right dose. Finding the right Synthroid dose for you may take some time. Keep in mind that everyone is unique.

During the first months of treatment, the doctor will work with you to find the right dose to get your TSH levels in range. The doctor will check how you’re doing on your prescribed Synthroid dose and ask you if you’re experiencing any symptoms. Since each person is unique, some people may need a low dose of Synthroid to help replace the amount of thyroid hormone that’s missing. Others may need a higher dose.

Synthroid helps restore thyroxine levels

With hypothyroidism, the thyroid hormone is too low.

With hypothyroidism, the thyroid hormone is too low
SYNTHROID replaces the thyroxine your thyroid can’t make anymore, helping restore your thyroxine levels

SYNTHROID replaces the thyroxine your thyroid can’t make anymore, helping restore your thyroxine levels.

Over time your thyroid hormone needs can change, and your dose of Synthroid might need to change as well. It’s important to continue your partnership with your doctor and discuss any symptoms you may be experiencing. After talking with you, your doctor may decide to recheck your TSH to determine if you need a change in dose. Remember, your medicine doesn’t work if you don’t take it. You play a major role in managing your hypothyroidism by taking your Synthroid every morning as prescribed by your doctor.

Synthroid 25 mcg orange

25 mcg

orange

Synthroid 50 mcg white

50 mcg

white

Synthroid 75 mcg violet

75 mcg

violet

Synthroid 88 mcg olive

88 mcg

olive

Synthroid 100 mcg yellow

100 mcg

yellow

Synthroid 112 mcg rose

112 mcg

rose

Synthroid 125 mcg brown

125 mcg

brown

Synthroid 137 mcg turquoise

137 mcg

turquoise

Synthroid 150 mcg blue

150 mcg

blue

Synthroid 175 mcg lilac

175 mcg

lilac

Synthroid 200 mcg pink

200 mcg

pink

Synthroid 300 mcg green

300 mcg

green

Tablets shown not actual size and
may not represent exact color.

About Synthroid Dosing

Doctors have been prescribing Synthroid for over 50 years. Synthroid comes in 12 dosing options to help doctors find the dose that’s right for you. Your doctor will determine your starting dose based on weight, age, cause of hypothyroidism, other health conditions you have, and other medications you are taking.

USE

SYNTHROID® (levothyroxine sodium) tablets, for oral use is a prescription, man-made thyroid hormone that is used to treat a condition called hypothyroidism. It is meant to replace a hormone that is usually made by your thyroid gland. Generally, thyroid replacement treatment is to be taken for life. SYNTHROID should not be used to treat noncancerous growths or enlargement of the thyroid in patients with normal iodine levels, or in cases of temporary hypothyroidism caused by inflammation of the thyroid gland (thyroiditis).

IMPORTANT SAFETY INFORMATION

  • Thyroid hormones, including SYNTHROID, should not be used either alone or in combination with other drugs for the treatment of obesity or weight loss. In patients with normal thyroid levels, doses of SYNTHROID used daily for hormone replacement are not helpful for weight loss. Larger doses may result in serious or even life-threatening events, especially when used in combination with certain other drugs used to reduce appetite.

  • Do not use SYNTHROID if you have uncorrected adrenal problems.

  • Taking too much levothyroxine has been associated with increased bone loss, especially in women after menopause.

  • Once your doctor has found your specific SYNTHROID dose, it is important to have lab tests done, as ordered by your doctor, at least once a year.

  • Foods like soybean flour, cottonseed meal, walnuts, and dietary fiber may cause your body to absorb less SYNTHROID from the gastrointestinal tract. Grapefruit juice may cause your body to absorb less levothyroxine and may reduce its effect. Let your doctor know if you eat these foods, as your dose of SYNTHROID may need to be adjusted.

  • Use SYNTHROID only as ordered by your doctor. Take SYNTHROID as a single dose, preferably on an empty stomach, one-half to one hour before breakfast.

  • Products such as iron and calcium supplements and antacids can lower your body’s ability to absorb levothyroxine, so SYNTHROID should be taken 4 hours before or after taking these products.

  • Tell your doctor if you are pregnant or breastfeeding or are thinking of becoming pregnant while taking SYNTHROID. Your dose of SYNTHROID may need to be increased during your pregnancy.

  • It may take several weeks before you notice an improvement in your symptoms.

  • Tell your doctor if you are taking any other drugs, including prescription and over-the-counter products.

  • Tell your doctor about any other medical conditions you may have, especially heart disease, diabetes, blood clotting problems, and adrenal or pituitary gland problems. The dose of other drugs you may be taking to control these conditions may have to be changed while you are taking SYNTHROID. If you have diabetes, check your blood sugar levels and/or the glucose in your urine, as ordered by your doctor, and immediately tell your doctor if there are any changes. If you are taking blood thinners, your blood clotting status should be checked often.

  • Tell your doctor or dentist that you are taking SYNTHROID before any surgery.

  • Tell your doctor if you develop any of the following symptoms: rapid or abnormal heartbeat, chest pain, difficulty catching your breath, leg cramps, headache, nervousness, irritability, sleeplessness, shaking, change in appetite, weight gain or loss, vomiting, diarrhea, increased sweating, difficulty tolerating heat, fever, changes in menstrual periods, swollen red bumps on the skin (hives) or skin rash, or any other unusual medical event.

  • Partial hair loss may occur during the first few months you are taking SYNTHROID.

This is the most important safety information you should know about SYNTHROID. For more information, talk with your doctor.

Click here for full Prescribing Information or go to http://www.rxabbvie.com/pdf/synthroid.pdf.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1‑800‑FDA‑1088.

If you cannot afford your medication, contact www.pparx.org for assistance.

SYNTHROID TABLETS ARE A PRESCRIPTION MEDICATION.